Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours

BACKGROUND: Plasma exposure of sunitinib shows large inter-individual variation. Therefore, a pharmacokinetic (PK) study was performed to determine safety and feasibility of sunitinib dosing based on PK levels. METHODS: Patients were treated with sunitinib 37.5 mg once daily. At days 15 and 29 of tr...

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Dades bibliogràfiques
Autors principals: Lankheet, N A G, Kloth, J S L, Gadellaa-van Hooijdonk, C G M, Cirkel, G A, Mathijssen, R H J, Lolkema, M P J K, Schellens, J H M, Voest, E E, Sleijfer, S, de Jonge, M J A, Haanen, J B A G, Beijnen, J H, Huitema, A D R, Steeghs, N
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
Clinical Study
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021528/
https://ncbi.nlm.nih.gov/pubmed/24736581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.194
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