Genetic, cytogenetic, and molecular analyses of mutations induced by melphalan demonstrate high frequencies of heritable deletions and other rearrangements from exposure of postspermatogonial stages of the mouse.

Specific-locus experiments have previously shown melphalan to be mutagenic in all male germ-cell stages tested and particularly so in early spermatids. All but 2 of 24 specific-locus mutations recovered were tested genetically, cytogenetically, and/or molecularly. At least 12 of 15 tested mutations...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Russell, L B, Hunsicker, P R, Cacheiro, N L, Rinchik, E M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC402146/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1352884/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.13.6182
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