Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes

Extracellular acidity is a frequent pathophysiological condition of solid tumors offering possibilities for improving the tumor selectivity of molecular therapy. This might be accomplished by prodrugs with low systemic toxicity, attaining their full antitumor potency only under acidic conditions, su...

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Detalhes bibliográficos
Main Authors: Valiahdi, Seied Mojtaba, Egger, Alexander E., Miklos, Walter, Jungwirth, Ute, Meelich, Kristof, Nock, Petra, Berger, Walter, Hartinger, Christian G., Galanski, Mathea Sophia, Jakupec, Michael A., Keppler, Bernhard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021454/
https://ncbi.nlm.nih.gov/pubmed/23354303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-012-0970-4
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