Toll-Like Receptor-4 deficiency enhances repair of ultraviolet radiation induced cutaneous DNA damage by nucleotide excision repair mechanism

UVB-induced DNA damage plays a critical role in development of photoimmunosuppression. The purpose of this study was to determine whether repair of UVB-induced DNA damage is regulated by Toll-like receptor-4 (TLR4). When TLR4 gene knockout (TLR4(-/-)) and TLR4 competent (TLR4(+/+)) mice were subject...

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Hauptverfasser: Ahmad, Israr, Simanyi, Eva, Guroji, Purushotham, Tamimi, Iman A, delaRosa, Hillary J, Nagar, Anusuiya, Nagar, Priyamvada, Katiyar, Santosh K, Elmets, Craig A, Yusuf, Nabiha
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020975/
https://ncbi.nlm.nih.gov/pubmed/24326454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.530
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