Real-time tracking of CO migration and binding in the α and β subunits of human hemoglobin via 150-ps time-resolved Laue crystallography

We have developed the method of picosecond Laue crystallography and used this capability to probe ligand dynamics in tetrameric R-state hemoglobin (Hb). Time-resolved, 2 Å-resolution electron density maps of photolyzed HbCO reveal the time-dependent population of CO in the binding (A) and primary do...

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Bibliographic Details
Main Authors: Schotte, Friedrich, Cho, Hyun Sun, Soman, Jayashree, Wulff, Michael, Olson, John S., Anfinrud, Philip A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020136/
https://ncbi.nlm.nih.gov/pubmed/24839343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chemphys.2012.12.030
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