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PET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody
BACKGROUND: Molecular imaging with positron emission tomography (PET) may allow the non-invasive study of the pharmacodynamic effects of agonistic monoclonal antibodies (mAb) to 4-1BB (CD137). 4-1BB is a member of the tumor necrosis factor family expressed on activated T cells and other immune cells...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019904/ https://ncbi.nlm.nih.gov/pubmed/24829750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-1426-1-14 |
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