PET imaging to non-invasively study immune activation leading to antitumor responses with a 4-1BB agonistic antibody

BACKGROUND: Molecular imaging with positron emission tomography (PET) may allow the non-invasive study of the pharmacodynamic effects of agonistic monoclonal antibodies (mAb) to 4-1BB (CD137). 4-1BB is a member of the tumor necrosis factor family expressed on activated T cells and other immune cells...

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Bibliografski detalji
Glavni autori: Escuin-Ordinas, Helena, Elliott, Mark W, Atefi, Mohammad, Lee, Michelle, Ng, Charles, Wei, Liu, Comin-Anduix, Begoña, Montecino-Rodriguez, Encarnacion, Avramis, Earl, Radu, Caius, Sharp, Leslie L, Ribas, Antoni
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019904/
https://ncbi.nlm.nih.gov/pubmed/24829750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-1426-1-14
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