PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and Aβ

Defects in p21-activated kinase (PAK) are suspected to play a role in cognitive symptoms of Alzheimer's disease (AD). Dysfunction in PAK leads to cofilin activation, drebrin displacement from its actin-binding site, actin depolymerization/severing, and, ultimately, defects in spine dynamics and...

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Bibliografische gegevens
Hoofdauteurs: Arsenault, Dany, Dal-Pan, Alexandre, Tremblay, Cyntia, Bennett, David A., Guitton, Matthieu J., De Koninck, Yves, Tonegawa, Susumu, Calon, Frédéric
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019789/
https://ncbi.nlm.nih.gov/pubmed/23804095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1501-13.2013
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