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Aprotinin, but not epsilon aminocaproic acid and tranexamic acid, exerts neuroprotection against excitotoxic injury in an in vitro neuronal cell culture model

OBJECTIVE: Lack of availability of aprotinin has resulted in increased clinical use of the alternative antifibrinolytic agents epsilon aminocaproic acid (EACA) and tranexamic acid (TXA) which are known to be associated with an increased risk of seizures. In contrast aprotinin has previously been dem...

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Main Authors: Lu, Zhaohui, Korotcova, Ludmila, Murata, Akira, Ishibashi, Nobuyuki, Jonas, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019727/
https://ncbi.nlm.nih.gov/pubmed/24237885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2013.09.054
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