Development of Rabbit Monoclonal Antibodies for Detection of Alpha-Dystroglycan in Normal and Dystrophic Tissue

Alpha-dystroglycan requires a rare O-mannose glycan modification to form its binding epitope for extracellular matrix proteins such as laminin. This functional glycan is disrupted in a cohort of muscular dystrophies, the secondary dystroglycanopathies, and is abnormal in some metastatic cancers. The...

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Detalhes bibliográficos
Main Authors: Fortunato, Marisa J., Ball, Charlotte E., Hollinger, Katrin, Patel, Niraj B., Modi, Jill N., Rajasekaran, Vedika, Nonneman, Dan J., Ross, Jason W., Kennedy, Eileen J., Selsby, Joshua T., Beedle, Aaron M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019581/
https://ncbi.nlm.nih.gov/pubmed/24824861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097567
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