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Impairment of Visual Function and Retinal ER Stress Activation in Wfs1-Deficient Mice
Wolfram syndrome is an early onset genetic disease (1/180,000) featuring diabetes mellitus and optic neuropathy, associated to mutations in the WFS1 gene. Wfs1−/− mouse model shows pancreatic beta cell atrophy, but its visual performance has not been investigated, prompting us to study its visual fu...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019519/ https://ncbi.nlm.nih.gov/pubmed/24823368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097222 |
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