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OPA1 gene therapy prevents retinal ganglion cell loss in a Dominant Optic Atrophy mouse model
Dominant optic atrophy (DOA) is a rare progressive and irreversible blinding disease which is one of the most frequent forms of hereditary optic neuropathy. DOA is mainly caused by dominant mutation in the OPA1 gene encoding a large mitochondrial GTPase with crucial roles in membrane dynamics and ce...
Tallennettuna:
| Julkaisussa: | Sci Rep |
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| Päätekijät: | , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group UK
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5802757/ https://ncbi.nlm.nih.gov/pubmed/29410463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20838-8 |
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