Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 (ILC2) and γδ T cells

Chitin, a polysaccharide constituent of many allergens and parasites, initiates innate type 2 lung inflammation through incompletely defined pathways. We show that inhaled chitin induced expression of three epithelial cytokines, interleukin-25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP),...

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Detalhes bibliográficos
Main Authors: Van Dyken, Steven J., Mohapatra, Alexander, Nussbaum, Jesse C., Molofsky, Ari B., Thornton, Emily E., Ziegler, Steven F., McKenzie, Andrew N. J., Krummel, Matthew F., Liang, Hong-Erh, Locksley, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019510/
https://ncbi.nlm.nih.gov/pubmed/24631157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.02.003
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