TRB3 Is Involved in Free Fatty Acid-Induced INS-1-Derived Cell Apoptosis via the Protein Kinase C δ Pathway

Chronic exposure to free fatty acids (FFAs) may induce β cell apoptosis in type 2 diabetes. However, the precise mechanism by which FFAs trigger β cell apoptosis is still unclear. Tribbles homolog 3 (TRB3) is a pseudokinase inhibiting Akt, a key mediator of insulin signaling, and contributes to insu...

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Main Authors: Qin, Jun, Fang, Ni, Lou, Jinning, Zhang, Wenjian, Xu, Shiqing, Liu, Honglin, Fang, Qing, Wang, Zai, Liu, Jiang, Men, Xiuli, Peng, Liang, Chen, Li
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019472/
https://ncbi.nlm.nih.gov/pubmed/24824999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096089
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