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Transgenic zebrafish model of the C43G human insulin gene mutation
AIMS/INTRODUCTION: The human insulin gene/preproinsulin protein mutation C43G disrupts disulfide bond formation and causes diabetes in humans. Previous in vitro studies showed that these mutant proteins are retained in the endoplasmic reticulum (ER), are not secreted and are associated with decrease...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley-Blackwell
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019270/ https://ncbi.nlm.nih.gov/pubmed/24843647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jdi.12015 |
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