Localization of hepatocyte nuclear factor‐4α in the nucleolus and nucleus is regulated by its C‐terminus

Aims/Introduction:  Mutations in hepatocyte nuclear factor‐4α (HNF4α) lead to various diseases, among which C‐terminal deletions of HNF4α are exclusively responsible for maturity onset diabetes of the young 1 (MODY1). MODY is an autosomal dominant disease characterized by a primary defect in insulin...

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Autors principals: Ogata, Makiko, Awaji, Takeo, Iwasaki, Naoko, Fujimaki, Risa, Takizawa, Miho, Maruyama, Kei, Bell, Graeme I, Iwamoto, Yasuhiko, Uchigata, Yasuko
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2012
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019245/
https://ncbi.nlm.nih.gov/pubmed/24843605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.2040-1124.2012.00210.x
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