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CD40-independent help by memory CD4 T cells induces pathogenic alloantibody but does not lead to long-lasting humoral immunity
CD40/CD154 interactions are essential for productive antibody responses to T-dependent antigens. Memory CD4 T cells express accelerated helper functions and are less dependent on costimulation when compared to naïve T cells. Here we report that donor-reactive memory CD4 T cells can deliver help to C...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019209/ https://ncbi.nlm.nih.gov/pubmed/24102790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12432 |
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