Sialic Acid Residues Are Essential for Cell Lysis Mediated by Leukotoxin from Aggregatibacter actinomycetemcomitans

Leukotoxin (LtxA) from Aggregatibacter actinomycetemcomitans is known to target and lyse β(2)-integrin-expressing cells such as polymorphonuclear leukocytes and macrophages. LtxA is an important virulence factor that facilitates chronic inflammation and is strongly associated with a fast-progressing...

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Detalhes bibliográficos
Main Authors: Munksgaard, Peter Svenssen, Skals, Marianne, Reinholdt, Jesper, Poulsen, Knud, Jensen, Maria Risager, Yang, Chuanxu, Leipziger, Jens, Vorup-Jensen, Thomas, Praetorius, Helle A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019149/
https://ncbi.nlm.nih.gov/pubmed/24643533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01647-14
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