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Virulence-Associated Genome Mutations of Murine Rotavirus Identified by Alternating Serial Passages in Mice and Cell Cultures
Although significant clinical efficacy and safety of rotavirus vaccines were recently revealed in many countries, the mechanism of their attenuation is not well understood. We passaged serially a cell culture-adapted murine rotavirus EB strain in mouse pups or in cell cultures alternately and repeat...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019127/ https://ncbi.nlm.nih.gov/pubmed/24599996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00041-14 |
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