The Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active Site

Encephalomyocarditis virus (EMCV) is a member of the Cardiovirus genus within the large Picornaviridae family, which includes a number of important human and animal pathogens. The RNA-dependent RNA polymerase (RdRp) 3D(pol) is a key enzyme for viral genome replication. In this study, we report the X...

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Detalhes bibliográficos
Main Authors: Vives-Adrian, Laia, Lujan, Celia, Oliva, Baldo, van der Linden, Lonneke, Selisko, Barbara, Coutard, Bruno, Canard, Bruno, van Kuppeveld, Frank J. M., Ferrer-Orta, Cristina, Verdaguer, Núria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019119/
https://ncbi.nlm.nih.gov/pubmed/24600002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03502-13
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