The Crystal Structure of Coxsackievirus B3 RNA-Dependent RNA Polymerase in Complex with Its Protein Primer VPg Confirms the Existence of a Second VPg Binding Site on Picornaviridae Polymerases

The RNA-dependent RNA polymerase (RdRp) is a central piece in the replication machinery of RNA viruses. In picornaviruses this essential RdRp activity also uridylates the VPg peptide, which then serves as a primer for RNA synthesis. Previous genetic, binding, and biochemical data have identified a V...

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Autors principals: Gruez, Arnaud, Selisko, Barbara, Roberts, Michael, Bricogne, Gérard, Bussetta, Cécile, Jabafi, Ilham, Coutard, Bruno, De Palma, Armando M., Neyts, Johan, Canard, Bruno
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Structure and Assembly
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546979/
https://ncbi.nlm.nih.gov/pubmed/18632861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00631-08
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