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Attenuation of Human Enterovirus 71 High-Replication-Fidelity Variants in AG129 Mice
In a screen for ribavirin resistance, a novel high-fidelity variant of human enterovirus 71 (EV71) with the single amino acid change L123F in its RNA-dependent RNA polymerase (RdRp or 3D) was identified. Based on the crystal structure of EV71 RdRp, L123 locates at the entrance of the RNA template bi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4019108/ https://ncbi.nlm.nih.gov/pubmed/24623423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00289-14 |
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