Boosting Functional Avidity of CD8(+) T Cells by Vaccinia Virus Vaccination Depends on Intrinsic T-Cell MyD88 Expression but Not the Inflammatory Milieu

T-cell functional avidity is a crucial determinant for efficient pathogen clearance. Although recombinant DNA priming coupled with a vaccinia-vectored vaccine (VACV) boost has been widely used to mount robust CD8(+) T-cell responses, how VACV boost shapes the properties of memory CD8(+) T cells rema...

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Detalhes bibliográficos
Main Authors: Hu, Zhidong, Wang, Jing, Wan, Yanmin, Zhu, Lingyan, Ren, Xiaonan, Qiu, Sugan, Ren, Yanqin, Yuan, Songhua, Ding, Xiangqing, Chen, Jian, Qiu, Chenli, Sun, Jun, Zhang, Xiaoyan, Xiang, Jim, Qiu, Chao, Xu, Jianqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019089/
https://ncbi.nlm.nih.gov/pubmed/24554667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03664-13
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