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Immunogenicity of coiled-coil based drug-free macromolecular therapeutics

A two-component CD20 (non-internalizing) receptor crosslinking system based on the biorecognition of complementary coiled-coil forming peptides was evaluated. Exposure of B cells to Fab’-peptide1 conjugate decorates the cell surface with peptide1; further exposure of the decorated cells to P-(peptid...

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Main Authors: Kverka, Miloslav, Hartley, Jonathan M., Chu, Te-Wei, Yang, Jiyuan, Heidchen, Regina, Kopeček, Jindřich
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019077/
https://ncbi.nlm.nih.gov/pubmed/24767787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.03.063
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