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Drug-Free Macromolecular Therapeutics: Induction of Apoptosis by Coiled-Coil Mediated Crosslinking of Antigens on Cell Surface
[Image: see text] A new paradigm was designed for apoptosis induction mediated by the biorecognition of coiled-coil motifs at the Raji B cell surface. The heterodimerization of complementary peptides, one bound to Fab’ antibody fragment, the other as grafts to HPMA copolymer, results in crosslinking...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2998410/ https://ncbi.nlm.nih.gov/pubmed/20101660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200906232 |
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