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Delineating the Structural Blueprint of the Pre-mRNA 3′-End Processing Machinery

Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in gene expression. Polyadenylation consists of two steps, cleavage and poly(A) synthesis, and requires multiple cis elements in the pre-mRNA and a megadalton protein complex bearing the two essential enzymatic activit...

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Autori principali: Xiang, Kehui, Tong, Liang, Manley, James L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019069/
https://ncbi.nlm.nih.gov/pubmed/24591651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00084-14
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