CLOCK-Controlled Polyphonic Regulation of Circadian Rhythms through Canonical and Noncanonical E-Boxes

In mammalian circadian clockwork, the CLOCK-BMAL1 complex binds to DNA enhancers of target genes and drives circadian oscillation of transcription. Here we identified 7,978 CLOCK-binding sites in mouse liver by chromatin immunoprecipitation-sequencing (ChIP-Seq), and a newly developed bioinformatics...

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Bibliografiske detaljer
Main Authors: Yoshitane, Hikari, Ozaki, Haruka, Terajima, Hideki, Du, Ngoc-Hien, Suzuki, Yutaka, Fujimori, Taihei, Kosaka, Naoki, Shimba, Shigeki, Sugano, Sumio, Takagi, Toshihisa, Iwasaki, Wataru, Fukada, Yoshitaka
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019033/
https://ncbi.nlm.nih.gov/pubmed/24591654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01465-13
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