Characterization of Reverse Genetics-Derived Cold-Adapted Master Donor Virus A/Leningrad/134/17/57 (H2N2) and Reassortants with H5N1 Surface Genes in a Mouse Model

Live attenuated influenza vaccines (LAIV) offer significant advantages over subunit or split inactivated vaccines to mitigate an eventual influenza pandemic, including simpler manufacturing processes and more cross-protective immune responses. Using an established reverse genetics (rg) system for wi...

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Detalhes bibliográficos
Main Authors: Isakova-Sivak, Irina, Chen, Li-Mei, Bourgeois, Melissa, Matsuoka, Yumiko, Voeten, J. Theo M., Heldens, Jacco G. M., van den Bosch, Han, Klimov, Alexander, Rudenko, Larisa, Cox, Nancy J., Donis, Ruben O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018889/
https://ncbi.nlm.nih.gov/pubmed/24648485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00819-13
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