Exome Sequencing Implicates an Increased Burden of Rare Potassium Channel Variants in the Risk of Drug Induced Long QT Syndrome

OBJECTIVES: To test the hypothesis that rare variants are associated with Drug-induced long QT syndrome (diLQTS) and torsade de pointes (TdP). BACKGROUND: diLQTS is associated with the potentially fatal arrhythmia TdP. The contribution of rare genetic variants to the underlying genetic framework pre...

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Detalhes bibliográficos
Main Authors: Weeke, Peter, Mosley, Jonathan D., Hanna, David, Delaney, Jessica T., Shaffer, Christian, Wells, Quinn S., Van Driest, Sara, Karnes, Jason H., Ingram, Christie, Guo, Yan, Shyr, Yu, Norris, Kris, Kannankeril, Prince J., Ramirez, Andrea H., Smith, Joshua D., Mardis, Elaine R., Nickerson, Deborah, George, Alfred L., Roden, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018823/
https://ncbi.nlm.nih.gov/pubmed/24561134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2014.01.031
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