Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling

IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We sho...

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Bibliographic Details
Main Authors: Lee, Naeun, Shin, Min Sun, Kang, Ki Soo, Yoo, Seung-Ah, Mohanty, Subhasis, Montgomery, Ruth R., Shaw, Albert C., Kang, Insoo
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018768/
https://ncbi.nlm.nih.gov/pubmed/24657713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.03.003
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