Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain

Previously, we showed that ADAM10 is necessary for HIV-1 replication in primary human macrophages and immortalized cell lines. Silencing ADAM10 expression interrupted the HIV-1 life cycle prior to nuclear translocation of viral cDNA. Furthermore, our data indicated that HIV-1 replication depends on...

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Huvudupphovsmän: Endsley, Mark A., Somasunderam, Anoma D., Li, Guangyu, Oezguen, Numan, Thiviyanathan, Varatharasa, Murray, James L., Rubin, Donald H., Hodge, Thomas W., O’Brien, William A., Lewis, Briana, Ferguson, Monique R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018752/
https://ncbi.nlm.nih.gov/pubmed/24725932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.02.006
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