The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

Lipopolysaccharide activates plasma-membrane signaling and endosomal signaling by Toll-like receptor 4 (TLR4) through the TIRAP-MyD88 and TRAM-TRIF adaptor complexes, respectively, but it is unclear how the signaling switch between these cell compartments is coordinated. In dendritic cells, we found...

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Main Authors: Aksoy, Ezra, Taboubi, Salma, Torres, David, Delbauve, Sandrine, Hachani, Abderrahman, Whitehead, Maria A, Pearce, Wayne P, Berenjeno, Inma M, Nock, Gemma, Filloux, Alain, Beyaert, Rudi, Flamand, Veronique, Vanhaesebroeck, Bart
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018573/
https://ncbi.nlm.nih.gov/pubmed/23023391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2426
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