Short Term Feeding of a High Fat Diet Exerts an Additive Effect on Hepatocellular Damage and Steatosis in Liver-Specific PTEN Knockout Mice

BACKGROUND: Hepatospecific deletion of PTEN results in constitutive activation of Akt and increased lipogenesis. In mice, the addition of a high fat diet (HFD) downregulates lipogenesis. The aim of this study was to determine the effects of a HFD on hepatocellular damage induced by deletion of PTEN....

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Autors principals: Shearn, Colin T., Mercer, Kelly E., Orlicky, David J., Hennings, Leah, Smathers-McCullough, Rebecca L., Stiles, Bangyan L., Ronis, Martin J. J., Petersen, Dennis R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018288/
https://ncbi.nlm.nih.gov/pubmed/24818992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096553
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