Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)

[Image: see text] Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) represents a promising strategy for the discovery of a new generation of anticancer chemotherapeutics. Our synthetic efforts, beginning from the lead compound 2, were directed at impro...

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Autors principals: Abe, Hiroyuki, Kikuchi, Shinichi, Hayakawa, Kazuhide, Iida, Tetsuya, Nagahashi, Noboru, Maeda, Katsuya, Sakamoto, Johei, Matsumoto, Noriaki, Miura, Tomoya, Matsumura, Koji, Seki, Noriyoshi, Inaba, Takashi, Kawasaki, Hisashi, Yamaguchi, Takayuki, Kakefuda, Reina, Nanayama, Toyomichi, Kurachi, Hironori, Hori, Yoshikazu, Yoshida, Takayuki, Kakegawa, Junya, Watanabe, Yoshihiro, Gilmartin, Aidan G., Richter, Mark C., Moss, Katherine G., Laquerre, Sylvie G.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2011
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018163/
https://ncbi.nlm.nih.gov/pubmed/24900312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200004g
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