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Benzodiazepinone Derivatives as CRTH2 Antagonists

[Image: see text] Multiple CRTH2 antagonists are currently evaluated in human clinical trials for asthma and chronic obstructive pulmonary disease (COPD). During our lead optimization for CRTH2 antagonists, an observation of an intramolecular hydrogen bond in ortho-phenylsulfonamido benzophenone der...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Jiwen (Jim), Cheng, Alan C., Tang, H. Lucy, Medina, Julio C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2011
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018144/
https://ncbi.nlm.nih.gov/pubmed/24900341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200019y
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