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A Strategy for Suppressing Redox Stress within Mitochondria

[Image: see text] An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do s...

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Detalhes bibliográficos
Main Authors: Arce, Pablo M., Khdour, Omar M., Goldschmidt, Ruth, Armstrong, Jeffrey S., Hecht, Sidney M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018135/
https://ncbi.nlm.nih.gov/pubmed/24900356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200095w
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