Design and Synthesis of Benzenesulfonamide Derivatives as Potent Anti-Influenza Hemagglutinin Inhibitors

[Image: see text] Structural optimization of salicylamide-based hemagglutinin (HA) inhibitor 1 resulted in the identification of cis-3-(5-hydroxy-1,3,3-trimethylcyclohexylmethylamino)benzenesulfonamide 28 and its derivatives as potent anti-influenza agents. The lead compound 28 and its 2-chloro anal...

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Detalhes bibliográficos
Main Authors: Tang, Guozhi, Lin, Xianfeng, Qiu, Zongxing, Li, Wentao, Zhu, Lei, Wang, Lisha, Li, Shaohua, Li, Haodong, Lin, Wenbin, Yang, Mei, Guo, Tao, Chen, Li, Lee, Daniel, Wu, Jim Z., Yang, Wengang
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018120/
https://ncbi.nlm.nih.gov/pubmed/24900355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2000627
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