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The Impact of Ionization States of Matrix Metalloproteinase Inhibitors on Docking-Based Inhibitor Design
[Image: see text] The influence of ionization states of hydroxamates and retrohydroxamates and the presence of zinc ions in the active site were investigated using the wild-type and E402Q mutant of MMP-9. The deprotonated hydroxamates showed a significantly enhanced enrichment factor in the presence...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2011
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018105/ https://ncbi.nlm.nih.gov/pubmed/24900330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200031m |
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