Novel Alkynylphosphonate Analogue of Calcitriol with Potent Antiproliferative Effects in Cancer Cells and Lack of Calcemic Activity

[Image: see text] Here, we describe the design and synthesis of diethyl [(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10(19)-trien-23-in-24-yl] phosphonate (compound 10), which combines the low calcemic properties of phosphonates with the decreased metabolic inactivation due to the presence of a...

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Detaylı Bibliyografya
Asıl Yazarlar: Salomón, Débora G., Grioli, Silvina M., Buschiazzo, Maximiliano, Mascaró, Evangelina, Vitale, Cristian, Radivoy, Gabriel, Perez, Manuel, Fall, Yagamare, Mesri, Enrique A., Curino, Alejandro C., Facchinetti, María M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2011
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018101/
https://ncbi.nlm.nih.gov/pubmed/24900339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200034w
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