Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors

[Image: see text] Phospoinositide-3-kinases (PI3K) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. A series of 2-morpholino, 4-substituted, 6-(3-hydroxyphenyl) pyrimidines have been reported as potent inhibitors of PI3Ks. Herein, w...

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Bibliografiset tiedot
Päätekijät: Burger, Matthew T., Knapp, Mark, Wagman, Allan, Ni, Zhi-Jie, Hendrickson, Thomas, Atallah, Gordana, Zhang, Yanchen, Frazier, Kelly, Verhagen, Joelle, Pfister, Keith, Ng, Simon, Smith, Aaron, Bartulis, Sarah, Merrit, Hanne, Weismann, Marion, Xin, Xiaohua, Haznedar, Joshua, Voliva, Charles F., Iwanowicz, Ed, Pecchi, Sabina
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2010
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018086/
https://ncbi.nlm.nih.gov/pubmed/24900252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1001932
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