Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors

[Image: see text] Phospoinositide-3-kinases (PI3K) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. A series of 2-morpholino, 4-substituted, 6-(3-hydroxyphenyl) pyrimidines have been reported as potent inhibitors of PI3Ks. Herein, w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Burger, Matthew T., Knapp, Mark, Wagman, Allan, Ni, Zhi-Jie, Hendrickson, Thomas, Atallah, Gordana, Zhang, Yanchen, Frazier, Kelly, Verhagen, Joelle, Pfister, Keith, Ng, Simon, Smith, Aaron, Bartulis, Sarah, Merrit, Hanne, Weismann, Marion, Xin, Xiaohua, Haznedar, Joshua, Voliva, Charles F., Iwanowicz, Ed, Pecchi, Sabina
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018086/
https://ncbi.nlm.nih.gov/pubmed/24900252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1001932
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados