Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB

[Image: see text] We discovered a potent retinoid X receptor (RXR) antagonist, 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid (13e), that is structurally closely related to the RXR full agonist 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinic acid (NEt-3IB)...

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Autores principales: Nakayama, Mariko, Yamada, Shoya, Ohsawa, Fuminori, Ohta, Yui, Kawata, Kohei, Makishima, Makoto, Kakuta, Hiroki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2011
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018080/
https://ncbi.nlm.nih.gov/pubmed/24900278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200197e
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