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Benzimidazoles as Potent and Orally Active mGlu5 Receptor Antagonists with an Improved PK Profile
[Image: see text] A focused chemical optimization effort of compound 1 based on metabolite elucidation is described, resulting in 15i, a highly potent and selective mGlu5 receptor antagonist with an improved pharmacokinetic profile compared to 1. Characterization of 15iin vivo in the fear-potentiate...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018045/ https://ncbi.nlm.nih.gov/pubmed/24900255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100215b |
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