Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B

[Image: see text] Novel colchicine derivatives possessing various substituents at the C4 position were prepared. Among them, 4-halo derivatives 3−6 were found to exhibit higher activity against cancer cell lines (A549, HT29, HCT116) as well as on mice transplanted with the HCT116 human colorectal ca...

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Detaylı Bibliyografya
Asıl Yazarlar: Yasobu, Naoko, Kitajima, Mariko, Kogure, Noriyuki, Shishido, Yoshiyuki, Matsuzaki, Takeshi, Nagaoka, Masato, Takayama, Hiromitsu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2011
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017992/
https://ncbi.nlm.nih.gov/pubmed/24900316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100287y
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