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Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B
[Image: see text] Novel colchicine derivatives possessing various substituents at the C4 position were prepared. Among them, 4-halo derivatives 3−6 were found to exhibit higher activity against cancer cell lines (A549, HT29, HCT116) as well as on mice transplanted with the HCT116 human colorectal ca...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4017992/ https://ncbi.nlm.nih.gov/pubmed/24900316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100287y |
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