The Vasa homolog RDE-12 engages target mRNA and multiple Argonaute proteins to promote RNAi in C. elegans

Argonaute proteins (AGOs) are key nuclease effectors of RNA interference (RNAi) [1]. Although purified AGOs can mediate a single round of target-RNA cleavage in vitro, accessory factors are required for short-interfering (si)RNAs loading and to achieve multiple-target turnover [2, 3]. To identify AG...

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Bibliografiske detaljer
Main Authors: Shirayama, Masaki, Stanney, William, Gu, Weifeng, Seth, Meetu, Mello, Craig C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017897/
https://ncbi.nlm.nih.gov/pubmed/24684931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.03.008
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