Genome-wide Transcriptome Profiling of Homologous Recombination DNA Repair

Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA-damage-inducing therapeutics. Here we identify an HR-defect (HRD) gene signature, which can be used to functionally assess HR repair status without interrogating individual gene...

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Detalhes bibliográficos
Main Authors: Peng, Guang, Lin, Curtis Chun-Jen, Mo, Wei, Dai, Hui, Park, Yun-Yong, Kim, Soo-Mi, Peng, Yang, Mo, Qianxing, Siwko, Stefan, Hu, Ruozhen, Lee, Ju-Seog, Hennessy, Bryan, Hanash, Samir, Mills, Gordon B., Lin, Shiaw-Yih
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017859/
https://ncbi.nlm.nih.gov/pubmed/24553445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4361
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