A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis

BACKGROUND: Fcγ receptors mediate important biological signals in myeloid cells including the ingestion of microorganisms through a process of phagocytosis. It is well-known that Fcγ receptor (FcγR) crosslinking induces the tyrosine phosphorylation of CBL which is associated with FcγR mediated phago...

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Hlavní autoři: Joshi, Shweta, Singh, Alok Ranjan, Zulcic, Muamera, Durden, Donald L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017086/
https://ncbi.nlm.nih.gov/pubmed/24886428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-15-18
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