Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

BACKGROUND: Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors often relapse, leading to a dismal outcome. The histone methyltransferase EZH2...

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Detalhes bibliográficos
Main Authors: Ciarapica, Roberta, Carcarino, Elena, Adesso, Laura, De Salvo, Maria, Bracaglia, Giorgia, Leoncini, Pier Paolo, Dall’Agnese, Alessandra, Verginelli, Federica, Milano, Giuseppe M, Boldrini, Renata, Inserra, Alessandro, Stifani, Stefano, Screpanti, Isabella, Marquez, Victor E, Valente, Sergio, Mai, Antonello, Puri, Pier Lorenzo, Locatelli, Franco, Palacios, Daniela, Rota, Rossella
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016511/
https://ncbi.nlm.nih.gov/pubmed/24575771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-139
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