DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics

BACKGROUND: De novo loss-of-function (dnLoF) mutations are found twofold more often in autism spectrum disorder (ASD) probands than their unaffected siblings. Multiple independent dnLoF mutations in the same gene implicate the gene in risk and hence provide a systematic, albeit arduous, path forward...

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Autores principales: Liu, Li, Lei, Jing, Sanders, Stephan J, Willsey, Arthur Jeremy, Kou, Yan, Cicek, Abdullah Ercument, Klei, Lambertus, Lu, Cong, He, Xin, Li, Mingfeng, Muhle, Rebecca A, Ma’ayan, Avi, Noonan, James P, Šestan, Nenad, McFadden, Kathryn A, State, Matthew W, Buxbaum, Joseph D, Devlin, Bernie, Roeder, Kathryn
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016412/
https://ncbi.nlm.nih.gov/pubmed/24602502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2392-5-22
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