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Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function.

The synthetic oligosaccharide moiety of the antibiotic calicheamicin and the head-to-head dimer of this oligosaccharide are known to bind to the minor groove of DNA in a sequence-selective manner preferring distinct target sequences. We tested these carbohydrates for their ability to interfere with...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Liu, C, Smith, B M, Ajito, K, Komatsu, H, Gomez-Paloma, L, Li, T, Theodorakis, E A, Nicolaou, K C, Vogt, P K
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40163/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570664/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.940
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