c-FLIP-Short Reduces Type I Interferon Production and Increases Viremia with Coxsackievirus B3

Cellular FLIP (c-FLIP) is an enzymatically inactive paralogue of caspase-8 and as such can block death receptor-induced apoptosis. However, independent of death receptors, c-FLIP-Long (c-FLIP(L)) can heterodimerize with and activate caspase-8. This is critical for promoting the growth and survival o...

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Главные авторы: Buskiewicz, Iwona A., Koenig, Andreas, Roberts, Brian, Russell, Jennifer, Shi, Cuixia, Lee, Sun-Hwa, Jung, Jae U., Huber, Sally A., Budd, Ralph C.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015977/
https://ncbi.nlm.nih.gov/pubmed/24816846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096156
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